Bmc res notes anticonvulsant effects of antiaris toxicaria aqueous extract. A new cytotoxic 19norcardenolide from the latex of. Their structures were established using ms and nmr spectroscopic studies, including. Este artigo sobre a ordem rosales, integrado no projeto plantas e um esboco. It can also be substituted for terminalia superba engl. Guide to trees of papua new guinea copyright held by the authors, national herbarium of new south wales, and papua new guinea. Antiaris e um genero botanico pertencente a familia moraceae. To study the chemical constituents of the antiaris toxicaria lesch leaves. Just type a new title, click go, and near the top of the results page, there will be a link to create the new page. Cardiac glycosides from the bark of antiaris toxicaria sciencedirect. Antiproliferative cardiac glycosides from the latex of.
The present work aims to develop and validate a reversedphase high performance liquid chromatography hplc method for quantification of convallatoxin in antiaris toxicaria leusch. There are several recognized subspecies, but only subsp. Bioassayguided fractionation of the extract led to identification of nine new cardiac glycosides 1. You can also create new pages using the search box. To evaluate the efficacy of a ghanaian herbal product prepared from the stem bark of antiaris toxicaria subsp. The database and code is licensed under a creative commons attributionnoncommercialsharealike 3. Antiaris toxicaria moraceae a new distribution record to the eastern ghats. Uses, benefits, cures, side effects, nutrients in antiaris toxicaria. Antiaris toxicaria herb uses, benefits, cures, side effects. Anticonvulsant effects of antiaris toxicaria aqueous extract. A new cytotoxic 19norcardenolide from the latex of antiaris toxicaria. All structured data from the file and property namespaces is available under the creative commons cc0 license. It is the only species currently recognized in the genus antiaris.
Files available from the acs website may be downloaded for personal use only. A handsome tree with the aspect of a large alnus, 3060 ft. Pdf evaluation of genetic diversity in antiaris toxicaria. The genus antiaris was at one time considered to comprise of several species, but is now regarded as just one variable species which can be further divided into five subspecies. Antiaris toxicaria is a tree in the mulberry and fig family, moraceae.
Structural features of the purified compounds were identified by analyzing the physicochemical properties and spectroscopy characteristics. This page was last edited on 22 december 2019, at 09. Cardiac glycosides from antiaris toxicaria with potent cardiotonic. In russian literature the name anchar, or upas tree, refers to a. Pdf a new cytotoxic 19norcardenolide from the latex of. Moraceae aqueous extract in rodents priscillakolibeamante,1 donatuswewuraadongo,1 ericwoode,1. Text is available under the creative commons attributionsharealike license. There are five or six species in the tropics of asia, africa, and madagascar. Antiaris toxicaria is one of such medicinal plants with a remarkably wide distribution in tropical regions.
Distributed throughout the high forest zone of west, central, and east africa on widely varying sites. Antiaris article about antiaris by the free dictionary. One significant difference within the species is that the size of the fruit increases as. Antiaris toxicaria aqueous extract therefore possesses anticonvulsant activity.
Their chemical structures were determined by ir, hresims, 1d and 2d nmr hsqc, 1 h 1 h cosy, hmbc, roesy. The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Antiaris toxicaria moraceae was evaluated for anticonvulsant activity in rodents. The leaf is used to remedy various ailments but the. This page was last edited on 22 august 2018, at 21. Creative commons attributionnoncommercialsharealike 3. Five new cardiac glycosides 15, namely antiaroside yzc together with 19 known compounds were obtained from the bark of antiaris toxicaria. Apr 26, 2017 antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. Antiaris toxicaria article about antiaris toxicaria by. How antiaris toxicaria is effective for various diseases is listed in repertory format. The name of the upas tree has become famous from the mendacious account professedly by one foersch, who was a surgeon.
The latex contains varying amounts of cardiac glycosides and can be very poisonous. There were a total of 3 compounds isolated from antiaris. Antiaris toxicaria is a tree in the mulberry and fig family of. Cardiac glycosides from antiaris toxicaria with potent.
Right now there are 404 articles and 1,254 registered users on this wiki. Iita headquarters pmb 5320, oyo road, ibadan 200001, oyo state. Antiaris toxicaria palta north 24 parganas 20120411 9602. Evaluation of genetic diversity in antiaris toxicaria lesch. The only species, antiaris toxicaria is found throughout the old world tropics, from west africa to madagascar, and in sri lanka, india, indochina, southern china, thailand, throughout the malesian region, the pacific east to fiji and tonga, and northern australia. Pdf antiaris toxicaria moraceae a new distribution record to. The preliminary phytochemical screening in different solvent extracts of antiaris toxicaria leaves, collected in the area anaikatti, coimbatore district exhibited variations in the presence of phytocompounds depends upon the polarity of solvents, the methanolic extract showed the presence of all phytoconstituents except alkaloids. Jul 23, 2010 an ethanolic extract of antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Compound 1 showed significant cytotoxicity against k562, sgc7901, smmc7721, and hela cell lines in vitro by mtt method.
Schum and can be used as a substitute for the latter. Increase in latency to seizures as well as reduction in duration and frequency of seizures indicated. Antiaris toxicaria herb uses, benefits, cures, side. Its structure was elucidated on the basis of hrfabms and spectroscopic techniques ir, uv, 1d and 2d nmr. The genome was 161,412 bp in length, comprising a large singlecopy region lsc of 89,883 bp, a. Antiaris toxicaria lesch welcome to pilikula nisarga dhama. Useful tropical plants database 2014 by ken fern, web interface by ajna fern with help from richard morris. Bioassayguided fractionation of the extract led to identification of 9 new cardiac glycosides 19, named antiarosides ai, antiarotoxinin a 10, and 18 known compounds.
Icr mice and spraguedawley rats were pretreated with aae 200800 mg. The genome was 161,412 bp in length, comprising a large singlecopy region lsc of 89,883 bp, a small singlecopy region ssc of 20,375 bp, and a pair. Anticonvulsant effects of antiaris toxicaria aqueous. Its seeds are spread by various birds and bats and it is not clear. Department of agriculture agricultural research service. The seed extract was analysed on c 18 column utilizing water and acetonitrile as mobile phase under isocratic elution at 220 nm, therefore this method can be used for standardization by estimation of. Antiaris toxicaria, pharmacognostic, leaf microscopy, anatomical sectioning. Upas, a javanese word meaning poison, and specially applied to the poison derived from the gum of the anchar tree antiaris toxicaria, a member of the figfamily moraceae, and a native of the sunda islands, which was commonly used to envenom the darts of the natives. List of various diseases cured by antiaris toxicaria. Peripheral neuropathy is a common neurologic disease that accounts for a lot of physician visits aims. Chromatographic methods were used to isolate and purify the chemical constituents.
An ethanolic extract of antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated. The seed extract was analysed on c 18 column utilizing water and acetonitrile as mobile phase under isocratic elution at 220 nm, therefore this method can be used for standardization by estimation of convallatoxin, a cardenolide in antiaris toxicaria. Antiaris toxicaria is a tree in the mulberry and fig family of moraceae. Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The genus antiaris was at one time considered to comprise several species, but is now regarded as just one variable species which can be further divided into five subspecies. A taxonomic genus within the family moraceae the upas tree.
The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor nur77 were examined in human nihh460 lung cancer cells. Animal models used include maximal electroshock test mest. Ipo, antiaris toxicarias, sacking tree herbal medicine. Several of the cardiac glycosides induced apoptosis in lung cancer cells, which. To facilitate species identification and provide genetic information, we determined the complete chloroplast genome of a. It has a remarkably wide distribution in tropical regions, occurring in australia, tropical asia, tropical africa, indonesia, philippines, tonga, and various other tropical islands. One significant difference within the species is that the size of the fruit increases. Quantification of convallatoxin in antiaris toxicaria.
Author links open overlay panel xiaosan li a mengjie hu b jie liu b qian liu a zhixing huang a shunlin li c xiaojiang hao c xiaokun zhang b xinsheng yao a jinshan. Cardiac glycosides from the bark of antiaris toxicaria. Antiaris toxicaria antiaris, moraceae is a medicinal and extremely toxic species. Reaches a height of 120 to 150 ft with a straight, cylindrical bole clear to 70 ft.
A new cytotoxic 19norcardenolide from the latex of antiaris. Names of antiaris toxicaria in various languages of the world are also given. One significant difference within the species is that the size of the fruit increases as you travel from africa to polynesia. Antiaris toxicaria in the germplasm resources information network grin, u. Jpg vinayara 30 january 20 creative commons attributionshare alike 3. An ethanolic extract of antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated guinea pig atria.
The complete chloroplast genome of antiaris toxicaria, a. Antiaris toxicaria article about antiaris toxicaria by the. A new norcardenolide, named toxicarioside h 1, was isolated from the latex of antiaris toxicaria pers. One significant difference within the species is that the size of the fruit. The genus antiaris was at one time considered to be comprised of several species, but is now regarded as just containing the one variable species antiaris toxicaria which can be further divided into five subspecies. Files are available under licenses specified on their description page.
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